Klotho and cancer

Author: ymyb

August undefined, 2024

WebKlotho functions as a tumor suppressor mainly by regulating insulin/IGF-1, p53/p21, and Wnt signaling pathways. Thus, Klotho involves in multiple biological processes, especially in anti-aging and inhibition of cancer, and it may be a potential key link between cancer and aging. WebThe effects of beta-Klotho and FGF-15 on the ileal apical sodium bile transporter (ASBT) are unknown. beta-Klotho siRNA treatment of the mouse colon cancer cell line, CT-26, and the human intrahepatic biliary epithelial cells (HIBEC) resulted in upregulation of endogenous ASBT expression that was associated with reduced expression of the ...

The KL-VS sequence variant of Klotho and cancer risk in BRCA1 …

WebIntroduction. Prostate cancer (PCa) is considered as the most diagnosed cancer for men in 2024 worldwide, with 191,930 new cases, accounting for almost 21.5% newly diagnosed cases in all types of cancer, the total deaths were up to 33,330, as a proportion of 10%. 1 Over the past decades, a steady increasement of PCa incidences and mortality in Asian … WebNov 17, 2024 · Klotho (α-Klotho) is located on Chromosome 13, and has been described as an anti-aging gene. It has two major isoforms, a 135 kDa transmembrane protein that serves as an obligatory co-receptor for FGF23, and a 70 kDa secreted form. how to feed sheep fs19

The anti-aging gene KLOTHO is a novel target for ... - Molecular …

WebJun 23, 2024 · Klotho was first discovered as an anti-ageing protein linked to a number of age-related disease processes, including cardiovascular, renal, musculoskeletal, and … WebMar 1, 2024 · Klotho is a newly identified kidney-protective factor ... (AKI) or AKI on CKD, infectious diseases, which included respiratory, digestive, and urinary tract infections, tumor or cancer, use of immunosuppressants, aged <18 years, and a history of renal replacement therapy or organ transplantation. Baseline demographic and clinical data, such as ... WebNew Publication by Junfeng Ma, et al. Initially discovered by Makuto Kuro-o in 1997, Klotho is a putative aging-suppressor gene when overexpressed and accelerates aging when … lee hill construction buyer

A Transgenic Model Reveals the Role of Klotho in …

Klotho rewires cellular metabolism of breast cancer cells …

WebOct 1, 2024 · In various tumor types, Klotho downregulation promotes cell proliferation and reduces cancer cell apoptosis. Soluble Klotho reduces tumor growth in vitro and in vivo in … WebCancer stem cells (CSC) play a crucial role in the process of tumor initiation, progression, recurrence, and drug resistance. ... Gunes et al. used CRISPR to up-regulate Klotho gene in colon cancer cell Caco-2, and found that cell proliferation was inhibited and tumorigenic recovery was achieved, ... how to feed sheep in fs22WebJul 19, 2010 · Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also serve as a potential tumor suppressor. how to feed sheep in farming simulator 22

"WebApr 8, 2024 · Long non-coding RNAs (lncRNAs) are a large, heterogeneous class of transcripts and key regulators of gene expression at both the transcriptional and post-transcriptional levels in different cellular contexts and biological processes. Understanding the potential mechanisms of action of lncRNAs and their role in disease onset and … " - Klotho and cancer

Klotho and cancer

Effects of Klotho on fibrosis and cancer: A renal focus on …

WebMar 11, 2011 · Klotho suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) responses in cultured cells, including decreased epithelial marker expression, increased mesenchymal marker expression, and/or increased cell migration. In addition to TGF-β1 signaling, secreted Klotho has been shown to inhibit Wnt and IGF-1 signaling that … WebNov 1, 2014 · It has been reported that KL, as a tumor suppressor, downregulates insulin growth factor (IGF) signaling pathway that is involved in tumorigenesis and progression of many human cancers, including...

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WebJul 5, 2011 · We have recently identified klotho as a tumor suppressor in breast cancer. Klotho is expressed in the normal pancreas and both the IGF-I and FGF pathways are … WebDec 15, 2024 · Klotho is an anti-aging transmembrane protein, which can be shed and can function as a hormone. Accumulating data indicate that klotho is a tumor suppressor in a wide array of malignancies, and ...

WebOct 19, 2024 · The protein Klotho can significantly delay aging, so it has attracted widespread attention. Abnormal downregulation of Klotho has been detected in several aging-related diseases, such as Alzheimer’s disease, kidney injury, cancer, chronic obstructive pulmonary disease (COPD), vascular disease, muscular dystrophy and … WebJul 16, 2024 · Klotho has both anticancer and hormone-like functions. But the research on Klotho and cancer is mainly based on animal experiments and small-scale clinical …

WebKlotho also plays a role in cancer, a disease that kills more than 500,000 Americans every year. Several studies show that Klotho levels are decreased in certain types of human … WebJul 5, 2013 · The klotho gene is a classical “aging suppressor” gene. Its roles in the pathology of chronic kidney diseases have been well documented. However, the role of Klotho in tumorigenesis, cancer progression, and prognosis is attracting more and more attention. Recent studies have shown that Klotho participates in the progression of …

WebJun 23, 2024 · (B) Klotho (KL) is a tumor-suppressor inhibiting pathways relevant for tumorigenesis including IGF-1R, Wnt/β-catenin, and NF-κB signaling, resulting in decreased cell proliferation, invasion,...

WebJun 17, 2024 · Purpose: We aimed to investigate the mechanisms of action on Klotho that underlie cancer development in RET fusion models of human papillary thyroid cancer (PTC). Materials and Methods: Normal Nthy-ori 3-1 thyroid cells and two PTC cell lines (BHP10-3 and TPC-1), which were used as RET fusion models of PTC, were used to study Klotho. how to feed saltwater fish while on vacationWebFeb 7, 2024 · Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation. Matrilin-2 is an ECM protein and has been found to elevate the pro-osteogenic activity in human aortic valve interstitial … how to feed sheep in minecraftWebJan 1, 2016 · Studies show that klotho is universally silenced in a wide array of malignancies, including breast, pancreatic, ovarian, lung, colorectal, and melanoma, and that klotho's expression can serve as an invaluable prognostic marker. how to feed silkwormWebSep 19, 2024 · Klotho is an anti-aging transmembrane protein, which can be shed and function as a hormone. Accumulating data indicate klotho as a tumor suppressor in a wide array of malignancies and indicate... lee hill automotive fredericksburg vaWebIntroduction. Prostate cancer (PCa) is considered as the most diagnosed cancer for men in 2024 worldwide, with 191,930 new cases, accounting for almost 21.5% newly diagnosed … how to feed skeleton horse minecraftWebJul 16, 2024 · Background. Klotho has both anticancer and hormone-like functions. But the research on Klotho and cancer is mainly based on animal experiments and small-scale clinical research, thus we explored the association between serum Klotho and cancer and cancer mortality based on the National Health and Nutrition Survey (NHANES). lee hill community center fredericksburg vaWebKlotho suppresses tumor growth, inhibits metastases, reduces resistance to chemo-therapy drugs and improves survival. Cancer is the leading cause of death in the US and new … how to feed skeleton horses minecraft