Cyp2a6 代謝
WebFernandez-Salguero et al. (1995) identified 3 different CYP2A6 alleles: the functional CYP2A6 allele; variant-1 (v1), which has a single base mutation (T to A) leading to a leu-to-his change in exon 3 (CYP2A6*2; 122720.0001); and v2, which is formed by gene conversion between the wildtype CYP2A6 and CYP2A7 genes in exons 3, 6, and 8 … Web消化管吸収後、体内でcyp2a6によって代謝され、抗悪性腫瘍作用を示すプロドラッグはどれか。1つ選べ。 1 テガフール 2 イリノテカン 3 ドキシフルリジン 4 サラゾスルファ …
Cyp2a6 代謝
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WebFeb 20, 2015 · VA Directive 6518 4 f. The VA shall identify and designate as “common” all information that is used across multiple Administrations and staff offices to serve VA … Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several … See more Click on genes, proteins and metabolites below to link to respective articles. See more CYP2A6 localizes to the endoplasmic reticulum and is found predominantly in the liver. See more CYP2A6 is known to be inducible by phenobarbital and rifampicin, and it is suspected that other antiepileptic drugs may also have this … See more • Pelkonen O, Rautio A, Raunio H, Pasanen M (2000). "CYP2A6: a human coumarin 7-hydroxylase". Toxicology. 144 (1–3): 139–47. doi:10.1016/S0300-483X(99)00200-0 See more Significant interindividual variability in CYP2A6 apoprotein and mRNA levels has been observed. See more • List of cytochrome P450 modulators See more • Human CPA6 genome location and CPA6 gene details page in the UCSC Genome Browser. • Human CYP2A6 genome location and CYP2A6 gene details page in the UCSC Genome Browser. See more
WebBarley Mill Court. Barlow House Court. Barnswallow Lane. Barnum Drive. Baron Court. Barrett Court. Barrett Heights Road. Barrington Court. Barrington Woods Boulevard. Web这个基因,cyp2a6,编码细胞色素p450酶超家族的一个成员。细胞色素p450蛋白是一种单加氧酶,催化药物代谢和胆固醇、类固醇等脂类的合成。该蛋白定位于内质网,由苯巴比妥诱导表达。这种酶是已知的羟基香豆素,也代谢尼古丁,黄曲霉毒素B1,亚硝胺和一些药物。
WebView/Edit Mouse. Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the … WebCORE – Aggregating the world’s open access research papers
Web17.3.1.4 CYP2A6. CYP2A6 is a member of the cytochrome P450 superfamily and is expressed predominantly in hepatic cells, with some expression in specialized extrahepatic cell types. Compared with CYP2D6 and CYP3A4, relatively few clinically used drugs are metabolized to a significant point by CYP2A6. Its substrates include coumarin, halothane ...
WebMar 21, 2024 · CYP2A6 (Cytochrome P450 Family 2 Subfamily A Member 6) is a Protein Coding gene. Diseases associated with CYP2A6 include Tobacco Addiction and Coumarin Resistance.Among its related pathways are Oxidation by cytochrome P450 and Metapathway biotransformation Phase I and II.Gene Ontology (GO) annotations related … marshall urgent care holly springsWeb17.3.1.4 CYP2A6. CYP2A6 is a member of the cytochrome P450 superfamily and is expressed predominantly in hepatic cells, with some expression in specialized extrahepatic cell types. Compared with CYP2D6 and CYP3A4, relatively few clinically used drugs are metabolized to a significant point by CYP2A6. Its substrates include coumarin, halothane ... marshall urology addressWebシトクロムp450 2d6 (cyp2d6) はシトクロムp450 (cyp) の分子種の一種であり、人体に存在する生体異物を代謝する酵素の主要なものの1つである。 主要な薬剤としては タモキ … marshall used vw golfWebDECEMBER 23, 2004 VA DIRECTIVE 5383 7. g. Section 503 of the Supplemental Appropriations Act of 1987, Public Law 100-71, 101 Stat. 391, 468-471, codified at Title 5 … marshall used cars florence kyWeb(3-pyridyl)-1-butanone(NNK)の代謝的活性化を担う. CYP2A13は主に肺に発現しており,CYP2A6と同様に NNK を代謝的に活性化するのに加え,ナフタレンや スチレンなどの異物の解毒に機能している.CYP2A6 と96.5%の塩基配列の相同性を示すCYP2A7は,肝臓 marshall urology associatesWebCYP2A6はテガフール、ファドロゾールおよびレトロゾールなどの抗がん薬の代謝に関与する.またこれまでにCYP2A6には遺伝子多型が存在することが知られている.しかしながら,これまでに報告されている遺伝子多型だけでは,日本人のpoor metabolizer(PM)を十分に説明することができない.そこで,日本人49 ... marshall urology wvWebガフールは cyp2a6 によりフルオ ロウラシルに変換される.前述した ように抗がん剤は併用して使用する 場合が多く,体内の cyp3a4 の量 には限りがある.これらの抗がん剤 が併用された場合には,代謝過程に おいて相互作用による副作用の発現 marshall urology boaz