Cisplatin ddtc

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August undefined, 2024

WebRats treated with cisplatin and then DDTC did not show a significant elevation of hearing threshold. DDTC-mediated protection was associated with higher levels of GSH (0.81 +/- 0.11 nmol/mg tissue), compared to 0.45 +/- 0.02 nmol/mg tissue following administration of cisplatin alone. WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), …

Cisplatin Injection: MedlinePlus Drug Information

WebCisplatin (CDDP) is a widely used antineoplastic agent, the administration of which is associated with dose-related toxicities. Currently, ototoxicity is the dose-limiting toxicity of cisplatin and difficult to prevent. The purpose of this study was to determine the ability of two substituted dithio … WebChromatogram shows the peak of chelating agent, diethyldithiocarbamate (DDTC), and cisplatin in terms of DDTC–platinum complex. from publication: Ex vivo localization and permeation of cisplatin ... development approach adalah

A Novel Analytical Method of Cisplatin Using the HPLC …

WebThe cisplatin was then treated with 100 µL of (10%) DDTC in 0.1 N NaOH and incubated in a water bath at 37°C for 30 min. The resultant Pt-DDTC complex formed was extracted with chloroform by vigorous vortex of the solution mixture, and then the chloroform layer collected was evaporated under vacuum. WebMar 1, 2024 · Cisplatin is the most widely used anticancer drug in the world. Mono-chloro and none-chloro complexes of cisplatin may be believed to be the activated … WebJan 29, 2024 · The DDTC-cisplatin compound was then extracted by chloroform. After the chloroform layer was absorbed and the argon dried, the residue was dissolved with ethyl acetate, centrifuged for 5 min, and the supernatant was taken for further analysis. Separations using chromatography were done using an LC-20AB (SPD-20A UV-VIS … development application shoalhaven council

Low-level (PPB) determination of cisplatin in cleaning

Cisplatin ddtc

National Center for Biotechnology Information

WebDiethyldithiocarbamate (DDTC), a chelating agent that is a major metabolite of disulfuram, has been proposed as a potential rescue agent to reduce toxicity following high-dose cisplatin (HDCP) therapy. In the present study, we examined the pharmcologic interaction of HDCP and DDTC given as rescue therapy. WebCisplatin treated rats showed depletion of GSH levels, while cisplatin+DDTC injected rats had GSH values similar to controls. SOD and GSH.Px activities were found to be 63 and 40% of control following cisplatin administration which increased to 109 and 75% of control with DDTC respectively.

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WebCisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. WebApr 7, 2002 · The reactions between cisplatin and DDTC, thiourea and thiosulfate were in vestigated in an unbu ﬀ ered 0.10–0.05 mol dm ⫺ 3 chloride medium at 37 ⬚ C. All reactions f ollow the rate la w ...

WebThis regimen of high-dose tamoxifen in combination with cisplatin can be safely administered. Serum tamoxifen levels comparable to concentrations required for enhancement of cisplatin sensitivity in vitro are clinically achievable with acceptable toxicity. The level of antitumor activity in nonsmall … WebThe sequence is consistent with the report that DDTC is the most eﬀective rescue agent discovered so far when administered after cisplatin. The activation parameters ∆H ≠ and ∆S ≠ have been determined and the …

WebDiethyldithiocarbamate (DDTC), a chelating agent that is a major metabolite of disulfuram, has been proposed as a potential rescue agent to reduce toxicity following high-dose cisplatin (HDCP) therapy. In the present study, we examined the pharmacologic interaction of HDCP and DDTC given as rescue therapy. WebMay 11, 2012 · Cisplatin is a prescription medicine used alone to treat bladder and ovarian cancer.It is also used together with other drugs to help treat testicular cancer, locally …

WebSep 27, 2008 · Cisplatin treated rats showed depletion of GSH levels, while cisplatin + DDTC injected rats had GSH values similar to controls. SOD and GSH.Px activities were found to be 63 and 40% of control following cisplatin administration which increased to 109 and 75% of control with DDTC respectively. Our findings suggest that cisplatin …

WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral … churches in kearney moWebCisplatin is also used alone or in combination with other medications to treat bladder cancer that can not be treated with surgery or radiation therapy alone. Cisplatin is in a class of … churches in kc mo development approach and life cycleWebThe cisplatin released from the nanoparticles triggered by GSH was successfully examined as [Pt(DDTC) 2] + (m/z 491.01) and [Pt(DDTC) 3] + (m/z 639.04) by MALDI-MS after derivatization using … development area category cannot be blankWebNational Center for Biotechnology Information development approach definitionWebFour new water soluble complexes of the formula [Pt(DA)(DDTC)]NO 3 (where DA is 2,2'-bipyridine, 1,10-phenanthroline, 1,2-diaminopropane, or 1,2-diaminocyclohexane, and DDTC is diethyldithiocarbamate anion) have been synthesized by reaction of platinum-diamine/diimine diaqua complex with sodium diethyldithiocarbamate in molar ratio of 1:1. … development approval process in malaysiaWebDiethyldithiocarbamate (DDTC), a chelating agent that is a major metabolite of disulfuram, has been proposed as a potential rescue agent to reduce toxicity following high-dose … development approach of supervision