WebAt UWMC, bivalirudin is monitored using the Direct Thrombin Inhibitor (DTI) assay (Plasma-Diluted Thrombin Time). Used instead of aPTT to monitor injectable DTI … Web50 min; Bivalirudin 25 min; Lepirudin 80 min), management of hemorrhagic complications is primarily supportive and interruption of treatment will be sufficient to reverse the anticoagulant effect. If patients require pharmacologic therapy to manage hemorrhagic complications, a Hematology/Coagulation consult is advised. Management of
Unfractionated heparin (UFH), LMWH, fondaparinux, argatroban, and
WebApixaban (Eliquis) 2.5mg bid – 10mg PO BID 24 hours 6 hours 3 days 24 hours Rivaroxaban (Xarelto) 15-20mg PO Daily or 15mg PO BID 24 hours 6 hours 3 days 24 hours Edoxaban (Savaysa) 30-60mg PO Daily 24 hours 6 hours 3 days 24 hours Dabigatran (Pradaxa) 75mg bid – 150mg BID 48 hours 6 hours 4 days 24 hours Dalteparin SQ … WebBivalirudin Apixaban/ Dabigatran/ Edoxaban/ Ravaroxaban Initiate apixaban, dabigatran, edoxaban, or rivaroxaban within 2 hours after discontinuation of bivalirudin. Bivalirudin … grandma hill\u0027s prize winning meatloaf
UpToDate
WebApixaban Warfarin When going from apixaban to warfarin, consider the use of parenteral anticoagulation as a bridge (eg, start heparin infusion or therapeutic enoxaparin AND warfarin 12 hours after last dose of apixaban and discontinue parenteral anticoagulant … WebApixaban* (Eliquis®) 8-15 hrs (renal ~ 27%) (longer in renal insufficiency) Any CrCl (apixaban is only 27% renally eliminated): Lower risk bleeding*: hold 1 day pre-procedure Higher risk bleeding*: hold 2 days pre-procedure Low risk bleeding*: resume 24hrs post-procedure High risk bleeding*: resume 48-72hrs post- procedure WebUW Medicine Standard Protocols – Initiation Dosing. Order standard heparin infusion with starting dose defaulted based on the indication. Order Loading Bolus, if warranted. Order goal anti-Xa level (low intensity 0.3-0.5 units/mL or regular intensity 0.3-0.7 units/mL). Order as needed Re-Bolus for subtherapeutic anti-Xa, if warranted. grandma hip hop